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From a physiological perspective, acid base homeostasis is tightly regulated by renal, pulmonary, and buffering systems that maintain arterial pH within the narrow range of 7.357.45

While the G site is conserved across GST isoforms, the H site and other regions may vary, providing opportunities to create more selective inhibitors that minimize off-target effects

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10.1038/nature14344 Nature 50 JiangT.ChuJ.ChenH.ChengH.SuJ.WangX.et al (2020)

As a tripeptide, glutathione is made up of multiple amino acids glutamine, glycine, and cysteine

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